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Article

Diacylglycerol lipase regulates lifespan and oxidative stress response by inversely modulating TOR signaling in Drosophila and C. elegans.

Aging cell - 1 Aug 2014

Lin Yen-Hung, Chen Yi-Chun, Kao Tzu-Yu, Lin Yi-Chun, Hsu Tzu-En, Wu Yi-Chun, Ja William W, Brummel Theodore J, Kapahi Pankaj, Yuh Chiou-Hwa, Yu Lin-Kwei, Lin Zhi-Han, You Ru-Jing, Jhong Yi-Ting, Wang Horng-Dar

Abstract excerpt

Target of rapamycin (TOR) signaling is a nutrient-sensing pathway controlling metabolism and lifespan. Although TOR signaling can be activated by a metabolite of diacylglycerol (DAG), phosphatidic acid (PA), the precise genetic mechanism through which DAG metabolism influences lifespan remains unknown. DAG is metabolized to either PA via the action of DAG kinase or 2-arachidonoyl-sn-glycerol by diacylglycerol...

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Identifiers

PMID: 24889782
DOI: 10.1111/acel.12232
PMCID: PMC4116436

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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