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Article

Hormonal control of C. elegans dauer formation and life span by a Rieske-like oxygenase.

Developmental cell - 1 Apr 2006

Rottiers Veerle, Motola Daniel L, Gerisch Birgit, Cummins Carolyn L, Nishiwaki Kiyoji, Mangelsdorf David J, Antebi Adam

Abstract excerpt

C. elegans diapause, gonadal outgrowth, and life span are regulated by a lipophilic hormone, which serves as a ligand to the nuclear hormone receptor DAF-12. A key step in hormone production is catalyzed by the CYP450 DAF-9, but the extent of the biosynthetic pathway is unknown. Here, we identify a conserved Rieske-like oxygenase, DAF-36, as a component in hormone metabolism. Mutants display larval developmental...

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PMID: 16563875
DOI: 10.1016/j.devcel.2006.02.008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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