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The precursor of PI(3,4,5)P3 alleviates aging by activating daf-18(Pten) and independent of daf-16

8 Sept 2020

Abstract excerpt

Abstract Aging is characterized by the loss of homeostasis and the general decline of physiological functions, accompanied by various degenerative diseases and increased rates of mortality. Aging targeting small molecule screens have been performed many times, however, few have focused on endogenous metabolic intermediates—metabolites. Here, using C. elegans lifespan assays, we conducted a worm metabolite screen...

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Share to Autophagy in Disease and Therapy
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PMID: 32901024
DOI: 10.1038/s41467-020-18280-4

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