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Article

Systematic lipidomic analysis of yeast protein kinase and phosphatase mutants reveals novel insights into regulation of lipid homeostasis.

Molecular biology of the cell - 15 Oct 2014

da Silveira Dos Santos Aline Xavier, Riezman Isabelle, Aguilera-Romero Maria-Auxiliadora, David Fabrice, Piccolis Manuele, Loewith Robbie, Schaad Olivier, Riezman Howard

Abstract excerpt

The regulatory pathways required to maintain eukaryotic lipid homeostasis are largely unknown. We developed a systematic approach to uncover new players in the regulation of lipid homeostasis. Through an unbiased mass spectrometry-based lipidomic screening, we quantified hundreds of lipid species, including glycerophospholipids, sphingolipids, and sterols, from a collection of 129 mutants in protein kinase and...

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Identifiers

PMID: 25143408
DOI: 10.1091/mbc.E14-03-0851
PMCID: PMC4196872

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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