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Article

Fatty acid synthase cooperates with glyoxalase 1 to protect against sugar toxicity.

PLoS genetics - 1 Feb 2015

Garrido Damien, Rubin Thomas, Poidevin Mickael, Maroni Brigitte, Le Rouzic Arnaud, Parvy Jean-Philippe, Montagne Jacques

Abstract excerpt

Fatty acid (FA) metabolism is deregulated in several human diseases including metabolic syndrome, type 2 diabetes and cancers. Therefore, FA-metabolic enzymes are potential targets for drug therapy, although the consequence of these treatments must be precisely evaluated at the organismal and cellular levels. In healthy organism, synthesis of triacylglycerols (TAGs)-composed of three FA units esterified to a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25692475
DOI: 10.1371/journal.pgen.1004995
PMCID: PMC4334898

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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