Article
Tor1/Sch9-regulated carbon source substitution is as effective as calorie restriction in life span extension.
PLoS genetics - 1 May 2009
Wei Min, Fabrizio Paola, Madia Federica, Hu Jia, Ge Huanying, Li Lei M, Longo Valter D
Abstract excerpt
The effect of calorie restriction (CR) on life span extension, demonstrated in organisms ranging from yeast to mice, may involve the down-regulation of pathways, including Tor, Akt, and Ras. Here, we present data suggesting that yeast Tor1 and Sch9 (a homolog of the mammalian kinases Akt and S6K) is a central component of a network that controls a common set of genes implicated in a metabolic switch from the TCA...
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