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Article

Activated FOXO-mediated insulin resistance is blocked by reduction of TOR activity.

Cell metabolism - 1 Aug 2006

Luong Nancy, Davies Claire R, Wessells Robert J, Graham Suzanne M, King M Todd, Veech Richard, Bodmer Rolf, Oldham Sean M

Abstract excerpt

Reducing insulin/IGF signaling allows for organismal survival during periods of inhospitable conditions by regulating the diapause state, whereby the organism stockpiles lipids, reduces fertility, increases stress resistance, and has an increased lifespan. The Target of Rapamycin (TOR) responds t...

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Identifiers

PMID: 16890541
DOI: 10.1016/j.cmet.2006.05.013

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-16890541-2026-09-04.1. Manifest publication-graph-cohort-2026-09-04.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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