Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Elongated TCR alpha chain CDR3 favors an altered CD4 cytokine profile.

BMC biology - 9 May 2014

Reynolds Catherine, Chong Deborah, Raynsford Eleanor, Quigley Kathryn, Kelly Deborah, Llewellyn-Hughes Julia, Altmann Daniel, Boyton Rosemary

Abstract excerpt

BACKGROUND: CD4 T lymphocyte activation requires T cell receptor (TCR) engagement by peptide/MHC (major histocompatibility complex) (pMHC). The TCR complementarity-determining region 3 (CDR3) contains variable α and β loops critical for pMHC recognition. During any immune response, tuning of TCR usage through progressive clonal selection occurs. Th1 and Th2 cells operate at different avidities for activation and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CD4-Positive T-Lymphocytes
Share to Cell Polarity

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Complementarity Determining Regions

Share to Immunization

Share to Intracellular Space

Share to Models, Immunological

Share to Receptors, Antigen, T-Cell, alpha-beta

Share to T-Lymphocytes, Helper-Inducer

Source

Open in PubMed Open full text

Identifiers

PMID: 24886643
DOI: 10.1186/1741-7007-12-32
PMCID: PMC4046507

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Elongated TCR alpha chain CDR3 favors an altered CD4 cytokine profile.PMID 24886643Read ↗

Comparative analysis of CDR 3 regions in paired human αβ CD 8 T cellsSemantic proximity Read ↗

Innate TCRβ-chain engagement drives human T cells toward distinct memory-like effector phenotypes with immunotherapeutic potentials.Semantic proximity Read ↗

Comprehensive analysis of αβT-cell receptor repertoires reveals signatures of thymic selectionSemantic proximity Read ↗

Repertoire analyses reveal TCR sequence features that influence T cell fateSemantic proximity Read ↗

Structural determinants of T-cell receptor bias in immunity.Semantic proximity Read ↗

A population of proinflammatory T cells coexpresses αβ and γδ T cell receptors in mice and humans.Semantic proximity Read ↗

Tools for fundamental analysis functions of TCR repertoires: a systematic comparisonSemantic proximity Read ↗

MHC-II alleles shape the CDR3 repertoires of conventional and regulatory naïve CD4+ T cells.Semantic proximity Read ↗

γ9δ2 T-Cell Expansion and Phenotypic Profile Are Reflected in the CDR3δ Repertoire of Healthy Adults.Semantic proximity Read ↗

High-affinity, peptide-specific T cell receptors can be generated by mutations in CDR1, CDR2 or CDR3.Semantic proximity Read ↗

Induction of Th1 and Th2 CD4+ T cell responses: the alternative approaches.Semantic proximity Read ↗

Gene expression profile of human T cells following a single stimulation of peripheral blood mononuclear cells with anti-CD3 antibodiesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.