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Article

Elongated TCR alpha chain CDR3 favors an altered CD4 cytokine profile.

BMC biology - 9 May 2014

Reynolds Catherine, Chong Deborah, Raynsford Eleanor, Quigley Kathryn, Kelly Deborah, Llewellyn-Hughes Julia, Altmann Daniel, Boyton Rosemary

Abstract excerpt

BACKGROUND: CD4 T lymphocyte activation requires T cell receptor (TCR) engagement by peptide/MHC (major histocompatibility complex) (pMHC). The TCR complementarity-determining region 3 (CDR3) contains variable α and β loops critical for pMHC recognition. During any immune response, tuning of TCR...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24886643
DOI: 10.1186/1741-7007-12-32
PMCID: PMC4046507

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24886643-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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