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Article

γ9δ2 T-Cell Expansion and Phenotypic Profile Are Reflected in the CDR3δ Repertoire of Healthy Adults.

Frontiers in immunology - 1 Jan 2022

Vyborova Anna, Janssen Anke, Gatti Lucrezia, Karaiskaki Froso, Yonika Austin, van Dooremalen Sanne, Sanders Jasper, Beringer Dennis X, Straetemans Trudy, Sebestyen Zsolt, Kuball Jürgen

Abstract excerpt

γ9δ2T cells fill a distinct niche in human immunity due to the unique physiology of the phosphoantigen-reactive γ9δ2TCR. Here, we highlight reproducible TCRδ complementarity-determining region 3 (CDR3δ) repertoire patterns associated with γ9δ2T cell proliferation and phenotype, thus providing evidence for the role of the CDR3δ in modulating in vivo T-cell responses. Features that determine γ9δ2TCR binding...

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Identifiers

PMID: 35874769
DOI: 10.3389/fimmu.2022.915366
PMCID: PMC9301380

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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