Article

Repertoire analyses reveal TCR sequence features that influence T cell fate

2021-06-24

Abstract excerpt

<h4>ABSTRACT</h4> T cells acquire a regulatory phenotype when their T cell receptors (TCRs) experience an intermediate-high affinity interaction with a self-peptide presented on MHC. Using TCR sequences from FACS-sorted human cells, we identified TCR features that shape affinity to these self-peptide-MHC complexes, finding that 1) CDR3β hydrophobicity and 2) certain TRBV genes promote Treg fate. We developed a sc...

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Literature Corpus work: 4340154d-f6e5-53eb-a369-3a50f010b7e3
DOI: 10.1101/2021.06.23.449653

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