Article
Induction of Th1 and Th2 CD4+ T cell responses: the alternative approaches.
Annual review of immunology - 1 Jan 1997
Constant S L, Bottomly K
Abstract excerpt
T helper lymphocytes can be divided into two distinct subsets of effector cells based on their functional capabilities and the profile of cytokines they produce. The Th1 subset of CD4+ T cells secretes cytokines usually associated with inflammation, such as IFN-gamma and TNF and induces cell-mediated immune responses. The Th2 subset produces cytokines such as IL-4 and IL-5 that help B cells to proliferate and...
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