Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Structural determinants of T-cell receptor bias in immunity.

Nature reviews. Immunology - 1 Dec 2006

Turner Stephen J, Doherty Peter C, McCluskey James, Rossjohn Jamie

Abstract excerpt

Antigen-specific T-cell responses induced by infection, transplantation, autoimmunity or hypersensitivity are characterized by cells expressing biased profiles of T-cell receptors (TCRs) that are selected from a diverse, naive repertoire. Here, we review the evidence for these TCR biases, focusing on crystallographic analysis of the structural constraints that determine the binding of a TCR to its ligand and the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetic Variation
Share to Immunity
Share to Mice

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Protein Conformation

Share to Receptors, Antigen, T-Cell

Share to T-Lymphocytes

Share to Viruses

Source

Identifiers

PMID: 17110956
DOI: 10.1038/nri1977

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Structural determinants of T-cell receptor bias in immunity.PMID 17110956Read ↗

TCR3d: The T cell receptor structural repertoire databaseSemantic proximity Read ↗

Comprehensive analysis of αβT-cell receptor repertoires reveals signatures of thymic selectionSemantic proximity Read ↗

Diversity-oriented approaches for interrogating T-cell receptor repertoire, ligand recognition, and function.Semantic proximity Read ↗

Germline-encoded V(D)J gene usage does not impose strict constraints on the epitope-specificity of T cell receptorsSemantic proximity Read ↗

An Engineered Switch in T Cell Receptor Specificity Leads to an Unusual but Functional Binding Geometry.Semantic proximity Read ↗

50 Years of structural immunologySemantic proximity Read ↗

Functional implications of T cell receptor diversity.Semantic proximity Read ↗

Tools for fundamental analysis functions of TCR repertoires: a systematic comparisonSemantic proximity Read ↗

Pre–T cell receptors topologically sample self-ligands during thymocyte β-selectionSemantic proximity Read ↗

Bohemian T cell receptors: sketching the repertoires of unconventional lymphocytes.Semantic proximity Read ↗

Sequence and Structural Analyses Reveal Distinct and Highly Diverse Human CD8+ TCR Repertoires to Immunodominant Viral AntigensSemantic proximity Read ↗

Our evolving understanding of the role of the γδ T cell receptor in γδ T cell mediated immunitySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.