A population of proinflammatory T cells coexpresses αβ and γδ T cell receptors in mice and humans.

doi:10.1084/jem.20190834

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Article

A population of proinflammatory T cells coexpresses αβ and γδ T cell receptors in mice and humans.

The Journal of experimental medicine - 4 May 2020

Edwards Sarah C, Sutton Caroline E, Ladell Kristin, Grant Emma J, McLaren James E, Roche Fiona, Dash Pradyot, Apiwattanakul Nopporn, Awad Walid, Miners Kelly L, Lalor Stephen J, Ribot Julie C, Baik Song, Moran Barry, McGinley Aoife, Pivorunas Valerie, Dowding Lori, Macoritto Michael, Paez-Cortez Jesus, Slavin Anthony, Anderson Graham, Silva-Santos Bruno, Hokamp Karsten, Price David A, Thomas Paul G, McLoughlin Rachel M, Mills Kingston H G

Abstract excerpt

T cells are classically recognized as distinct subsets that express αβ or γδ TCRs. We identify a novel population of T cells that coexpress αβ and γδ TCRs in mice and humans. These hybrid αβ-γδ T cells arose in the murine fetal thymus by day 16 of ontogeny, underwent αβ TCR-mediated positive selection into CD4+ or CD8+ thymocytes, and constituted up to 10% of TCRδ+ cells in lymphoid organs. They expressed high...

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PMID: 32106283
DOI: 10.1084/jem.20190834
PMCID: PMC7201916

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