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Article

T-cell responses to sequentially emerging viral escape mutants shape long-term HIV-1 population dynamics.

PLoS pathogens - 1 Dec 2020

Akahoshi Tomohiro, Gatanaga Hiroyuki, Kuse Nozomi, Chikata Takayuki, Koyanagi Madoka, Ishizuka Naoki, Brumme Chanson J, Murakoshi Hayato, Brumme Zabrina L, Oka Shinichi, Takiguchi Masafumi

Abstract excerpt

HIV-1 strains harboring immune escape mutations can persist in circulation, but the impact of selection by multiple HLA alleles on population HIV-1 dynamics remains unclear. In Japan, HIV-1 Reverse Transcriptase codon 135 (RT135) is under strong immune pressure by HLA-B*51:01-restricted and HLA-B*52:01-restricted T cells that target a key epitope in this region (TI8; spanning RT codons 128-135). Major...

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Identifiers

PMID: 33370400
DOI: 10.1371/journal.ppat.1009177
PMCID: PMC7833229

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