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Article

Effects of a Single Escape Mutation on T Cell and HIV-1 Co-adaptation.

Cell reports - 7 Jun 2016

Sun Xiaoming, Shi Yi, Akahoshi Tomohiro, Fujiwara Mamoru, Gatanaga Hiroyuki, Schönbach Christian, Kuse Nozomi, Appay Victor, Gao George F, Oka Shinichi, Takiguchi Masafumi

Abstract excerpt

The mechanistic basis for the progressive accumulation of Y(135)F Nef mutant viruses in the HIV-1-infected population remains poorly understood. Y(135)F viruses carry the 2F mutation within RW8 and RF10, which are two HLA-A(∗)24:02-restricted superimposed Nef epitopes recognized by distinct and adaptable CD8(+) T cell responses. We combined comprehensive analysis of the T cell receptor repertoire and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 27239036
DOI: 10.1016/j.celrep.2016.05.017

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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