Article
Collaboration of a Detrimental HLA-B*35:01 Allele with HLA-A*24:02 in Coevolution of HIV-1 with T Cells Leading to Poorer Clinical Outcomes.
Journal of virology - 9 Nov 2021
Kuse Nozomi, Murakoshi Hayato, Akahoshi Tomohiro, Chikata Takayuki, James Katherine L, Gatanaga Hiroyuki, Rowland-Jones Sarah L, Oka Shinichi, Takiguchi Masafumi
Abstract excerpt
Although mutant-specific T cells are elicited in some individuals infected with HIV-1 mutant viruses, the detailed characteristics of these T cells remain unknown. A recent study showed that the accumulation of strains expressing Nef135F, which were selected by HLA-A*24:02-restricted T cells, was associated with poor outcomes in individuals with the detrimental HLA-B*35:01 allele and that HLA-B*35:01-restricted...
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