Article
The deubiquitinase activity of A20 is dispensable for NF-κB signaling.
EMBO reports - 1 Jul 2014
De Arnab, Dainichi Teruki, Rathinam Chozha Vendan, Ghosh Sankar
Abstract excerpt
A20 has been suggested to limit NF-κB activation by removing regulatory ubiquitin chains from ubiquitinated substrates. A20 is a ubiquitin-editing enzyme that removes K63-linked ubiquitin chains from adaptor proteins, such as RIP1, and then conjugates them to K48-linked polyubiquitin chains to trigger proteasomal degradation. To determine the role of the deubiquitinase function of A20 in downregulating NF-κB...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.