Article
Non-catalytic ubiquitin binding by A20 prevents psoriatic arthritis-like disease and inflammation.
Nature immunology - 1 Apr 2020
Razani Bahram, Whang Michael I, Kim Francis S, Nakamura Mary C, Sun Xiaofei, Advincula Rommel, Turnbaugh Jessie A, Pendse Mihir, Tanbun Priscilia, Achacoso Philip, Turnbaugh Peter J, Malynn Barbara A, Ma Averil
Abstract excerpt
A20 is an anti-inflammatory protein that is strongly linked to human disease. Here, we find that mice expressing three distinct targeted mutations of A20's zinc finger 7 (ZF7) ubiquitin-binding motif uniformly developed digit arthritis with features common to psoriatic arthritis, while mice expressing point mutations in A20's OTU or ZF4 motifs did not exhibit this phenotype. Arthritis in A20ZF7 mice required T...
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