Article
A20 in inflammation and autoimmunity.
Trends in immunology - 1 Jan 2014
Catrysse Leen, Vereecke Lars, Beyaert Rudi, van Loo Geert
Abstract excerpt
Although known for many years as a nuclear factor (NF)-κB inhibitory and antiapoptotic signaling protein, A20 has recently attracted much attention because of its ubiquitin-regulatory activities and qualification by genome-wide association studies (GWASs) as a susceptibility gene for inflammatory disease. Here, we review new findings that have shed light on the molecular and biochemical mechanisms by which A20...
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