Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation.

doi:10.1038/nature16165

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Article

Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation.

Nature - 17 Dec 2015

Wertz Ingrid E, Newton Kim, Seshasayee Dhaya, Kusam Saritha, Lam Cynthia, Zhang Juan, Popovych Nataliya, Helgason Elizabeth, Schoeffler Allyn, Jeet Surinder, Ramamoorthi Nandhini, Kategaya Lorna, Newman Robert J, Horikawa Keisuke, Dugger Debra, Sandoval Wendy, Mukund Susmith, Zindal Anuradha, Martin Flavius, Quan Clifford, Tom Jeffrey, Fairbrother Wayne J, Townsend Michael, Warming Søren, DeVoss Jason, Liu Jinfeng, Dueber Erin, Caplazi Patrick, Lee Wyne P, Goodnow Christopher C, Balazs Mercedesz, Yu Kebing, Kolumam Ganesh, Dixit Vishva M

Abstract excerpt

Inactivation of the TNFAIP3 gene, encoding the A20 protein, is associated with critical inflammatory diseases including multiple sclerosis, rheumatoid arthritis and Crohn's disease. However, the role of A20 in attenuating inflammatory signalling is unclear owing to paradoxical in vitro and in vivo findings. Here we utilize genetically engineered mice bearing mutations in the A20 ovarian tumour (OTU)-type...

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PMID: 26649818
DOI: 10.1038/nature16165

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TNFAIP3

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