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Article

The Deubiquitinase OTULIN Is an Essential Negative Regulator of Inflammation and Autoimmunity

1 Aug 2016

Abstract excerpt

Methionine-1 (M1)-linked ubiquitin chains regulate the activity of NF-κB, immune homeostasis, and responses to infection. The importance of negative regulators of M1-linked chains in vivo remains poorly understood. Here, we show that the M1-specific deubiquitinase OTULIN is essential for preventing TNF-associated systemic inflammation in humans and mice. A homozygous hypomorphic mutation in human OTULIN causes a...

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Identifiers

PMID: 27523608
DOI: 10.1016/j.cell.2016.07.019

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Deubiquitinase OTULIN Is an Essential Negative Regulator of Inflammation and AutoimmunityPMID 27523608Read ↗

OTULIN Antagonizes LUBAC Signaling by Specifically Hydrolyzing Met1-Linked PolyubiquitinSemantic proximity Read ↗

The binding of OTULIN restrains LUBAC activity to prevent TNF-driven immunopathologySemantic proximity Read ↗

A de novo dominant-negative variant is associated with OTULIN-related autoinflammatory syndrome.Semantic proximity Read ↗

Dominant negative OTULIN Related Autoinflammatory SyndromeSemantic proximity Read ↗

An Update on Autoinflammatory Diseases: Relopathies.Semantic proximity Read ↗

Homozygous<i>OTULIN</i>Variant Linked to OTULIN-Related Autoinflammatory Syndrome with Abscess FormationSemantic proximity Read ↗

Biallelic hypomorphic mutations in a linear deubiquitinase define otulipenia, an early-onset autoinflammatory disease.Semantic proximity Read ↗

OTULIN deficiency: focus on innate immune system impairment.Semantic proximity Read ↗

OTULIN prevents liver inflammation and hepatocellular carcinoma by inhibiting FADD- and RIPK1 kinase-mediated hepatocyte apoptosisSemantic proximity Read ↗

Mutations of deubiquitinase OTUD1 are associated with autoimmune disorders.Semantic proximity Read ↗

Canonical Wnt induction by OTULIN prevents keratinocyte death and skin inflammationSemantic proximity Read ↗

Immune defects caused by mutations in the ubiquitin system.Semantic proximity Read ↗

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