Article
A20 prevents chronic liver inflammation and cancer by protecting hepatocytes from death.
Cell death & disease - 2 Jun 2016
Catrysse L, Farhang Ghahremani M, Vereecke L, Youssef S A, Mc Guire C, Sze M, Weber A, Heikenwalder M, de Bruin A, Beyaert R, van Loo G
Abstract excerpt
An important regulator of inflammatory signalling is the ubiquitin-editing protein A20 that acts as a break on nuclear factor-κB (NF-κB) activation, but also exerts important cytoprotective functions. A20 knockout mice are cachectic and die prematurely due to excessive multi-organ inflammation. To establish the importance of A20 in liver homeostasis and pathology, we developed a novel mouse line lacking A20...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.