Article
NF-kappaB suppression by the deubiquitinating enzyme Cezanne: a novel negative feedback loop in pro-inflammatory signaling.
The Journal of biological chemistry - 14 Mar 2008
Enesa Karine, Zakkar Mustafa, Chaudhury Hera, Luong Le A, Rawlinson Lesley, Mason Justin C, Haskard Dorian O, Dean Jonathan L E, Evans Paul C
Abstract excerpt
Transcription factors belonging to the NF-kappaB family regulate inflammation by inducing pro-inflammatory molecules (e.g. interleukin (IL)-8) in response to cytokines (e.g. tumor necrosis factor (TNF) alpha, IL-1) or other stimuli. Several negative regulators of NF-kappaB, including the ubiquitin-editing enzyme A20, participate in the resolution of inflammatory responses. We report that Cezanne, a member of the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.