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Article

An Update on Autoinflammatory Diseases: Relopathies.

Current rheumatology reports - 30 May 2018

Steiner Annemarie, Harapas Cassandra R, Masters Seth L, Davidson Sophia

Abstract excerpt

PURPOSE OF REVIEW: The nuclear factor κB (NF-κB) pathway is tightly regulated through multiple posttranslational mechanisms including ubiquitination. Mutations in these regulatory pathways can cause disease and are the focus of this review. RECENT FINDINGS: The linear ubiquitin chain assembly complex (LUBAC) is a trimer made up of HOIL-1L, SHARPIN, and the catalytic subunit HOIP. Loss of function mutations in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 29846841
DOI: 10.1007/s11926-018-0749-x

Genes

OTULIN
NLRP3
SHARPIN
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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