Article
The Structure of a High-Affinity Kainate Receptor: GluK4 Ligand-Binding Domain Crystallized with Kainate.
Structure (London, England : 1993) - 6 Sept 2016
Kristensen Ole, Kristensen Lise Baadsgaard, Møllerud Stine, Frydenvang Karla, Pickering Darryl S, Kastrup Jette Sandholm
Abstract excerpt
Ionotropic glutamate receptors play a key role in fast neurotransmission in the CNS and have been linked to several neurological diseases and disorders. One subfamily is the kainate receptors, which are grouped into low-affinity (GluK1-3) and high-affinity (GluK4-5) receptors based on their affinity for kainate. Although structures of the ligand-binding domain (LBD) of all low-affinity kainate receptors have been...
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