Article
Dominance of the lurcher mutation in heteromeric kainate and AMPA receptor channels.
The European journal of neuroscience - 1 Sept 2001
Schwarz M K, Pawlak V, Osten P, Mack V, Seeburg P H, Köhr G
Abstract excerpt
Homomeric glutamate receptor (GluR) channels become spontaneously active when the last alanine residue within the invariant SYTANLAAF-motif in the third membrane segment is substituted by threonine. The same mutation in the orphan GluRdelta2 channel is responsible for neurodegeneration in "Lurcher" (Lc) mice. Since most native GluRs are composed of different subunits, we investigated the effect of an Lc-mutated...
Topics
- Amino Acid Substitution
- Animals
- Cell Line
- Electrophysiology
- Humans
- Ion Channel Gating
- Kidney
- Membrane Potentials
- Mice
- Mice, Neurologic Mutants
- Mutation
- Phenotype