Article
Identification of critical functional determinants of kainate receptor modulation by auxiliary protein Neto2.
The Journal of physiology - 15 Nov 2015
Griffith Theanne N, Swanson Geoffrey T
Abstract excerpt
KEY POINTS: Kainate receptors (KARs) are ionotropic glutamate receptors (iGluRs) that modulate synaptic transmission and intrinsic neuronal excitability. KARs associate with the auxiliary proteins neuropilin- and tolloid-like 1 and 2 (Neto1 and Neto2), which act as allosteric modulators of receptor function impacting all biophysical properties of these receptors studied to date. M3-S2 linkers play a critical role...
Topics
- Amino Acid Sequence
- Animals
- Binding Sites
- HEK293 Cells
- Humans
- Membrane Proteins
- Molecular Sequence Data
- Mutation
- Protein Binding
- Rats
- Receptors, Kainic Acid
- GluK2 Kainate Receptor