Article
The histone deacetylases sir2 and rpd3 act on ribosomal DNA to control the replication program in budding yeast.
Molecular cell - 22 May 2014
Yoshida Kazumasa, Bacal Julien, Desmarais Damien, Padioleau Ismaël, Tsaponina Olga, Chabes Andrei, Pantesco Véronique, Dubois Emeric, Parrinello Hugues, Skrzypczak Magdalena, Ginalski Krzysztof, Lengronne Armelle, Pasero Philippe
Abstract excerpt
In S. cerevisiae, replication timing is controlled by epigenetic mechanisms restricting the accessibility of origins to limiting initiation factors. About 30% of these origins are located within repetitive DNA sequences such as the ribosomal DNA (rDNA) array, but their regulation is poorly understood. Here, we have investigated how histone deacetylases (HDACs) control the replication program in budding yeast....
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