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Article

A genetic screen for ribosomal DNA silencing defects identifies multiple DNA replication and chromatin-modulating factors.

Molecular and cellular biology - 1 Apr 1999

Smith J S, Caputo E, Boeke J D

Abstract excerpt

Transcriptional silencing in Saccharomyces cerevisiae occurs at several genetic loci, including the ribosomal DNA (rDNA). Silencing at telomeres (telomere position effect [TPE]) and the cryptic mating-type loci (HML and HMR) depends on the silent information regulator genes, SIR1, SIR2, SIR3, and SIR4. However, silencing of polymerase II-transcribed reporter genes integrated within the rDNA locus (rDNA silencing)...

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Source

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Identifiers

PMID: 10082585
DOI: 10.1128/MCB.19.4.3184
PMCID: PMC84112

Genes

IRS4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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A genetic screen for ribosomal DNA silencing defects identifies multiple DNA replication and chromatin-modulating factors.PMID 10082585Read ↗

Distribution of a limited Sir2 protein pool regulates the strength of yeast rDNA silencing and is modulated by Sir4p.Semantic proximity Read ↗

Two classes of sir3 mutants enhance the sir1 mutant mating defect and abolish telomeric silencing in Saccharomyces cerevisiae.Semantic proximity Read ↗

A novel allele of SIR2 reveals a heritable intermediate state of gene silencing.Semantic proximity Read ↗

The SIR2 gene family, conserved from bacteria to humans, functions in silencing, cell cycle progression, and chromosome stability.Semantic proximity Read ↗

The NAD(+)-dependent Sir2p histone deacetylase is a negative regulator of chromosomal DNA replication.Semantic proximity Read ↗

Recruitment of Rpd3 to the telomere depends on the protein arginine methyltransferase Hmt1.Semantic proximity Read ↗

Sif2p interacts with Sir4p amino-terminal domain and antagonizes telomeric silencing in yeast.Semantic proximity Read ↗

The histone deacetylases sir2 and rpd3 act on ribosomal DNA to control the replication program in budding yeast.Semantic proximity Read ↗

SIR3 and SIR4 proteins are required for the positioning and integrity of yeast telomeres.Semantic proximity Read ↗

Identification of a novel allele of SIR3 defective in the maintenance, but not the establishment, of silencing in Saccharomyces cerevisiae.Semantic proximity Read ↗

Disturbance of normal cell cycle progression enhances the establishment of transcriptional silencing in Saccharomyces cerevisiae.Semantic proximity Read ↗

Silencing in yeast rDNA chromatin: reciprocal relationship in gene expression between RNA polymerase I and II.Semantic proximity Read ↗

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