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Article

Renal phosphate wasting in the absence of adenylyl cyclase 6.

Journal of the American Society of Nephrology : JASN - 1 Dec 2014

Fenton Robert A, Murray Fiona, Dominguez Rieg Jessica A, Tang Tong, Levi Moshe, Rieg Timo

Abstract excerpt

Parathyroid hormone (PTH) and fibroblast growth factor 23 (FGF-23) enhance phosphate excretion by the proximal tubule of the kidney by retrieval of the sodium-dependent phosphate transporters (Npt2a and Npt2c) from the apical plasma membrane. PTH activates adenylyl cyclase (AC) through PTH 1 receptors and stimulates the cAMP/PKA signaling pathway. However, the precise role and isoform(s) of AC in phosphate...

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Identifiers

PMID: 24854272
DOI: 10.1681/ASN.2013101102
PMCID: PMC4243352

Genes

PTH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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