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Article

Adenylyl cyclase 6 deficiency ameliorates polycystic kidney disease.

Journal of the American Society of Nephrology : JASN - 1 Feb 2014

Rees Sara, Kittikulsuth Wararat, Roos Karl, Strait Kevin A, Van Hoek Alfred, Kohan Donald E

Abstract excerpt

cAMP is an important mediator of cystogenesis in polycystic kidney disease (PKD). Several adenylyl cyclase (AC) isoforms could mediate cAMP accumulation in PKD, and identification of a specific pathogenic AC isoform is of therapeutic interest. We investigated the role of AC6 in a mouse model of PKD that is homozygous for the loxP-flanked PKD1 gene and heterozygous for an aquaporin-2-Cre recombinase transgene to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Kidney Failure, Chronic

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Share to Polycystic Kidney, Autosomal Dominant

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Source

Open in PubMed Open full text

Identifiers

PMID: 24158982
DOI: 10.1681/ASN.2013010077
PMCID: PMC3904559

Genes

ADCY6
PKD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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