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Article

In vivo treatment with calcilytic of CaSR knock-in mice ameliorates renal phenotype reversing downregulation of the vasopressin-AQP2 pathway.

The Journal of physiology - 1 Jul 2024

Ranieri Marianna, Angelini Ines, D'Agostino Mariagrazia, Di Mise Annarita, Centrone Mariangela, Venneri Maria, Ferrulli Angela, Mastrodonato Maria, Tamma Grazia, Endo Itsuro, Fukumoto Seiji, Matsumoto Toshio, Valenti Giovanna

Abstract excerpt

High concentrations of urinary calcium counteract vasopressin action via the activation of the Calcium-Sensing Receptor (CaSR) expressed in the luminal membrane of the collecting duct cells, which impairs the trafficking of aquaporin-2 (AQP2). In line with these findings, we provide evidence that, with respect to wild-type mice, CaSR knock-in (KI) mice mimicking autosomal dominant hypocalcaemia, display a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 38367250
DOI: 10.1113/JP284233

Genes

AQP2
ATF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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