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Article

The calcium-sensing receptor promotes urinary acidification to prevent nephrolithiasis.

Journal of the American Society of Nephrology : JASN - 1 Aug 2009

Renkema Kirsten Y, Velic Ana, Dijkman Henry B, Verkaart Sjoerd, van der Kemp Annemiete W, Nowik Marta, Timmermans Kim, Doucet Alain, Wagner Carsten A, Bindels René J, Hoenderop Joost G

Abstract excerpt

Hypercalciuria increases the risk for urolithiasis, but renal adaptive mechanisms reduce this risk. For example, transient receptor potential vanilloid 5 knockout (TPRV5(-/-)) mice lack kidney stones despite urinary calcium (Ca(2+)) wasting and hyperphosphaturia, perhaps as a result of their significant polyuria and urinary acidification. Here, we investigated the mechanisms linking hypercalciuria with these...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19470676
DOI: 10.1681/ASN.2008111195
PMCID: PMC2723980

Genes

TRPV5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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