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Article

GPRC6A null mice exhibit osteopenia, feminization and metabolic syndrome.

PloS one - 1 Jan 2008

Pi Min, Chen Ling, Huang Min-Zhao, Zhu Wenyu, Ringhofer Brian, Luo Junming, Christenson Lane, Li Benyi, Zhang Jianghong, Jackson P David, Faber Pieter, Brunden Kurt R, Harrington John J, Quarles L Darryl

Abstract excerpt

BACKGROUND: GPRC6A is a widely expressed orphan G-protein coupled receptor that senses extracellular amino acids, osteocalcin and divalent cations in vitro. The physiological functions of GPRC6A are unknown. METHODS/PRINCIPAL FINDINGS: In this study, we created and characterized the phenotype of GPRC6A(-/-) mice. We observed complex metabolic abnormalities in GPRC6A(-/-) mice involving multiple organ systems that...

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Identifiers

PMID: 19050760
DOI: 10.1371/journal.pone.0003858
PMCID: PMC2585477

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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