Article
Activation of a non-cAMP/PKA signaling pathway downstream of the PTH/PTHrP receptor is essential for a sustained hypophosphatemic response to PTH infusion in male mice.
Endocrinology - 1 May 2013
Guo Jun, Song Lige, Liu Minlin, Segawa Hiroko, Miyamoto Ken-Ichi, Bringhurst F Richard, Kronenberg Henry M, Jüppner Harald
Abstract excerpt
PTH increases urinary Pi excretion by reducing expression of two renal cotransporters [NaPi-IIa (Npt2a) and NaPi-IIc (Npt2c)]. In contrast to acute transporter regulation that is cAMP/protein kinase A dependent, long-term effects require phospholipase C (PLC) signaling by the PTH/PTHrP receptor (PPR). To determine whether the latter pathway regulates Pi through Npt2a and/or Npt2c, wild-type mice (Wt) and animals...
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