Article
Genetic variants of the FADS1 FADS2 gene cluster as related to essential fatty acid metabolism.
Current opinion in lipidology - 1 Feb 2010
Lattka Eva, Illig Thomas, Koletzko Berthold, Heinrich Joachim
Abstract excerpt
PURPOSE OF REVIEW: The delta-5 and delta-6 desaturases have long been known to be important enzymes in the endogenous formation of long-chain polyunsaturated fatty acids (LC-PUFAs). Cloning of the coding sequences and chromosomal localization of the desaturase encoding genes fatty acid desaturase 1 and 2 (FADS1 and FADS2) opened the way for analyses of genetic factors as regulators of desaturase activity and...
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