Article
FaSD-somatic: a fast and accurate somatic SNV detection algorithm for cancer genome sequencing data.
Bioinformatics (Oxford, England) - 1 Sept 2014
Wang Weixin, Wang Panwen, Xu Feng, Luo Ruibang, Wong Maria Pik, Lam Tak-Wah, Wang Junwen
Abstract excerpt
UNLABELLED: Recent advances in high-throughput sequencing technologies have enabled us to sequence large number of cancer samples to reveal novel insights into oncogenetic mechanisms. However, the presence of intratumoral heterogeneity, normal cell contamination and insufficient sequencing depth, together pose a challenge for detecting somatic mutations. Here we propose a fast and an accurate somatic...
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