Article
Systematic comparison of somatic variant calling performance among different sequencing depth and mutation frequency.
Scientific reports - 26 Feb 2020
Chen Zixi, Yuan Yuchen, Chen Xiaoshi, Chen Jiayun, Lin Shudai, Li Xingsong, Du Hongli
Abstract excerpt
In the past decade, treatments for tumors have made remarkable progress, such as the successful clinical application of targeted therapies. Nowadays, targeted therapies are based primarily on the detection of mutations, and next-generation sequencing (NGS) plays an important role in relevant clinical research. The mutation frequency is a major problem in tumor mutation detection and increasing sequencing depth is...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.