Article
Comparison of somatic mutation calling methods in amplicon and whole exome sequence data.
BMC genomics - 28 Mar 2014
Xu Huilei, DiCarlo John, Satya Ravi Vijaya, Peng Quan, Wang Yexun
Abstract excerpt
BACKGROUND: High-throughput sequencing is rapidly becoming common practice in clinical diagnosis and cancer research. Many algorithms have been developed for somatic single nucleotide variant (SNV) detection in matched tumor-normal DNA sequencing. Although numerous studies have compared the performance of various algorithms on exome data, there has not yet been a systematic evaluation using PCR-enriched amplicon...
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