Article
Comparative Evaluation of Mutect2, Strelka2, and FreeBayes for Somatic SNV Detection in Synthetic and Clinical Whole-Exome Sequencing Data.
Biomolecules - 30 Oct 2025
López-Cade Igor, Gómez-Sanz Alicia, Sanvicente Adrián, Díaz-Tejeiro Cristina, Manzano Aránzazu, Pérez-Segura Pedro, Győrffy Balázs, Ocaña Alberto, de la Hoya Miguel, García-Barberán Vanesa
Abstract excerpt
Somatic variant calling is a critical step in cancer genome analysis, but the performance of available tools can vary depending on their underlying algorithms and filtering strategies. We compared three widely used variant callers-Mutect2, Strelka2, and FreeBayes-for their performance in somatic single-nucleotide variant (SNV) detection using both synthetic and real whole-exome sequencing (WES) data. Synthetic...
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