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SomaticSeq: An Ensemble and Machine Learning Method to Detect Somatic Mutations.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2020

Fang Li Tai

Abstract excerpt

A standard strategy to discover somatic mutations in a cancer genome is to use next-generation sequencing (NGS) technologies to sequence the tumor tissue and its matched normal (commonly blood or adjacent normal tissue) for side-by-side comparison. However, when interrogating entire genomes (or even just the coding regions), the number of sequencing errors easily outnumbers the number of real somatic mutations by...

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PMID: 32124311
DOI: 10.1007/978-1-0716-0327-7_4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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