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Article

In-depth comparison of somatic point mutation callers based on different tumor next-generation sequencing depth data.

Scientific reports - 22 Nov 2016

Cai Lei, Yuan Wei, Zhang Zhou, He Lin, Chou Kuo-Chen

Abstract excerpt

Four popular somatic single nucleotide variant (SNV) calling methods (Varscan, SomaticSniper, Strelka and MuTect2) were carefully evaluated on the real whole exome sequencing (WES, depth of ~50X) and ultra-deep targeted sequencing (UDT-Seq, depth of ~370X) data. The four tools returned poor consensus on candidates (only 20% of calls were with multiple hits by the callers). For both WES and UDT-Seq, MuTect2 and...

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Identifiers

PMID: 27874022
DOI: 10.1038/srep36540
PMCID: PMC5118795

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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