Cortical thickness mediates the relationship between DRD2 C957T polymorphism and executive function across the adult lifespan.

doi:10.1007/s00429-020-02169-5

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Article

Cortical thickness mediates the relationship between DRD2 C957T polymorphism and executive function across the adult lifespan.

Brain structure & function - 1 Jan 2021

Miranda Giuseppe G, Rodrigue Karen M, Kennedy Kristen M

Abstract excerpt

Dopamine (DA) signaling is critical for optimal cognitive performance. Aging is accompanied by a change in the strength of this signaling, with a loss of striatal and extrastriatal D2 binding potential. The reduction in dopamine modulation with age negatively influences various aspects of cognition. DRD2 C957T (rs6277) impacts DA D2 receptor density and availability, with C homozygotes linked to lower striatal DA...

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Identifiers

PMID: 33179159
DOI: 10.1007/s00429-020-02169-5
PMCID: PMC7855542

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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