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Article

Genetic Variation of a DRD2 Co-expression Network is Associated with Changes in Prefrontal Function After D2 Receptors Stimulation.

Cerebral cortex (New York, N.Y. : 1991) - 1 Mar 2019

Selvaggi Pierluigi, Pergola Giulio, Gelao Barbara, Di Carlo Pasquale, Nettis Maria Antonietta, Amico Graziella, Fazio Leonardo, Rampino Antonio, Sambataro Fabio, Blasi Giuseppe, Bertolino Alessandro

Abstract excerpt

Dopamine D2 receptors (D2Rs) contribute to the inverted U-shaped relationship between dopamine signaling and prefrontal function. Genetic networks from post-mortem human brain revealed 84 partner genes co-expressed with DRD2. Moreover, eight functional single nucleotide polymorphisms combined into a polygenic co-expression index (PCI) predicted co-expression of this DRD2 network and were associated with...

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Identifiers

PMID: 29415163
DOI: 10.1093/cercor/bhy022

Genes

DRD2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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