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Article

D4 receptor gene variation modulates activation of prefrontal cortex during working memory.

The European journal of neuroscience - 1 Nov 2007

Herrmann M J, Walter A, Schreppel T, Ehlis A-C, Pauli P, Lesch K-P, Fallgatter A J

Abstract excerpt

It has been shown that dopamine (DA) influences performance on neurocognitive tests, which are thought to rely on prefrontal activity. The purpose of this study was to explore the effects of gene polymorphisms related to DA activity, namely the D4 DA receptor (DRD4) gene exon III polymorphisms, on prefrontal cortex (PFC) activation. In this study we measured the brain oxygenation of the PFC during an n-back task...

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Source

Identifiers

PMID: 17970718
DOI: 10.1111/j.1460-9568.2007.05921.x

Genes

DRD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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