DRD2 genotype-based variation of default mode network activity and of its relationship with striatal DAT binding.

doi:10.1093/schbul/sbr128

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Article

DRD2 genotype-based variation of default mode network activity and of its relationship with striatal DAT binding.

Schizophrenia bulletin - 1 Jan 2013

Sambataro Fabio, Fazio Leonardo, Taurisano Paolo, Gelao Barbara, Porcelli Annamaria, Mancini Marina, Sinibaldi Lorenzo, Ursini Gianluca, Masellis Rita, Caforio Grazia, Di Giorgio Annabella, Niccoli-Asabella Artor, Popolizio Teresa, Blasi Giuseppe, Bertolino Alessandro

Abstract excerpt

The default mode network (DMN) comprises a set of brain regions with "increased" activity during rest relative to cognitive processing. Activity in the DMN is associated with functional connections with the striatum and dopamine (DA) levels in this brain region. A functional single-nucleotide polymorphism within the dopamine D2 receptor gene (DRD2, rs1076560 G > T) shifts splicing of the 2 D2 isoforms, D2 short...

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PMID: 21976709
DOI: 10.1093/schbul/sbr128
PMCID: PMC3523900

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DRD2
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