Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Directed evolution of improved zinc finger methyltransferases.

PloS one - 1 Jan 2014

Chaikind Brian, Ostermeier Marc

Abstract excerpt

The ability to target DNA methylation toward a single, user-designated CpG site in vivo may have wide applicability for basic biological and biomedical research. A tool for targeting methylation toward single sites could be used to study the effects of individual methylation events on transcription, protein recruitment to DNA, and the dynamics of such epigenetic alterations. Although various tools for directing...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Binding Sites
Share to Directed Molecular Evolution
Share to Gene Library

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Methylation

Share to Methyltransferases

Share to Mutation

Share to Zinc Fingers

Source

Open in PubMed Open full text

Identifiers

PMID: 24810747
DOI: 10.1371/journal.pone.0096931
PMCID: PMC4014571

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Directed evolution of improved zinc finger methyltransferases.PMID 24810747Read ↗

Site-selective in vivo targeting of cytosine-5 DNA methylation by zinc-finger proteins.Semantic proximity Read ↗

Altering the sequence specificity of HaeIII methyltransferase by directed evolution using in vitro compartmentalization.Semantic proximity Read ↗

Engineering of restriction endonucleases: using methylation activity of the bifunctional endonuclease Eco57I to select the mutant with a novel sequence specificity.Semantic proximity Read ↗

DNA methyltransferase enhanced <i>Fusobacterium nucleatum</i> geneticsSemantic proximity Read ↗

Directed evolution of an enhanced and highly efficient FokI cleavage domain for zinc finger nucleases.Semantic proximity Read ↗

Methylome-dependent transformation of <i>emm</i> 1 group A streptococciSemantic proximity Read ↗

Conditional DNA repair mutants enable highly precise genome engineering.Semantic proximity Read ↗

Screening for catalytically active Type II restriction endonucleases using segregation-induced methylation deficiency.Semantic proximity Read ↗

Mutations that confer de novo activity upon a maintenance methyltransferase.Semantic proximity Read ↗

Enhanced Fusobacterium nucleatum Genetics Using Host DNA Methyltransferases To Bypass Restriction-Modification SystemsSemantic proximity Read ↗

Rapid detection of functional expression of C-5-DNA methyltransferases in yeast.Semantic proximity Read ↗

Methylome Diversification through Changes in DNA Methyltransferase Sequence SpecificitySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.