Article
Site-selective in vivo targeting of cytosine-5 DNA methylation by zinc-finger proteins.
Nucleic acids research - 15 Nov 2003
Carvin Christopher D, Parr Rebecca D, Kladde Michael P
Abstract excerpt
Cytosine-5 DNA methylation is a critical signal defining heritable epigenetic states of transcription. As aberrant methylation patterns often accompany disease states, the ability to target cytosine methylation to preselected regions could prove valuable in re-establishing proper gene regulation. We employ the strategy of targeted gene methylation in yeast, which has a naturally unmethylated genome, selectively...
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