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Article

Mutations that confer de novo activity upon a maintenance methyltransferase.

Journal of molecular biology - 20 Sept 1991

Kelleher J E, Daniel A S, Murray N E

Abstract excerpt

DNA methyltransferases are not only sequence specific in their action, but they also differentiate between the alternative methylation states of a target site. Some methyltransferases are equally active on either unmethylated or hemimethylated DNA and consequently function as de novo methyltransferases. Others are specific for hemimethylated target sequences, consistent with the postulated role of a maintenance...

Topics

Bacteriophage lambda
Chromosomes, Bacterial
DNA Modification Methylases
Escherichia coli
Methylation
Mutation
Phenotype
Viral Proteins

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 1833555
DOI: 10.1016/0022-2836(91)80064-2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1833555-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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