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Methylome Diversification through Changes in DNA Methyltransferase Sequence Specificity

10 Apr 2014

Abstract excerpt

Epigenetic modifications such as DNA methylation have large effects on gene expression and genome maintenance. Helicobacter pylori, a human gastric pathogen, has a large number of DNA methyltransferase genes, with different strains having unique repertoires. Previous genome comparisons suggested that these methyltransferases often change DNA sequence specificity through domain movement--the movement between and...

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PMID: 24722038
DOI: 10.1371/journal.pgen.1004272

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